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64 RENAL DYSFUNCTION AND NEPHROTOXICITY We have alluded to the potential for decreases in GSH concentration to impair GSH conjugation and modify the metabolic fate of many compounds

Mirkovic N, Voehringer DW, Story MD, McConkey DJ, McDonnell TJ, Meyn RE: Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols

208,209,210 GSDMD-N binds to membrane lipids, such as cardiolipin and phosphoinositide, and crosslinks to oligomers, thereby forming membrane pores with inner diameters ranging from 10 to 14 nm

Crossbreeding Gprc5a -ko mice with SPC-dnIB- mice to generated Gprc5a / /SPC-dnIB- mice, in which dominant negative (dn) or super-repressor (SR) IB gene is driven by the type II cell marker surfactant protein C (SPC) promoter [30]