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In the causal process, the product of the a path quantifies the effect of independent variables (l-carnitine, betaine or DMG) on the mediator (TMAO), and the product of the b path quantifies the effect of the mediator (TMAO) on the dependent variable (NAFLD), controlling for independent variables (Reference Sobel19)

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The American Journal Of Medicine 2021, 135: 273-275

According to the number and location of the catalytic cysteines, Prxs are divided into three classes: the typical 2-Cys, the atypical 2-Cys and the 1-Cys [46]