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The STEP trials, for instance, combined semaglutide with lifestyle intervention including dietary counselling aimed at a 500-600 calorie deficit

Many individuals report improvements in energy, mental clarity, and metabolic function

Fatigue can happen for some patients, especially early in treatment or after a dosage adjustment

Some dentists recommend a remineralizing toothpaste or gel containing hydroxyapatite, which directly repairs enamel without relying on saliva to deliver minerals