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The SUMMIT trial, involving 731 individuals with HFpEF and obesity followed for a median of 104 weeks, revealed a 38% decrease in the composite endpoint of cardiovascular mortality or heart-failure deterioration events (HR: 0.62, 95%CI: 0.41-0.95, P = 0.026), driven primarily by fewer worsening heart-failure events (8.0% vs

The dosing schedule begins with 0.25 mg once weekly for four weeks (to improve tolerability), then increases to 0.5 mg weekly

Assessing the rest of the gastrointestinal tract in addition to gastric emptying provides information about motility in various segments of the gut, which can change management and improve symptoms

Yerba Mate The Claims: Some studies suggest yerba mate may stimulate GLP-1 and reduce appetite