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a) Somatostatin b) Glucagon c) Ghrelin d) Cortisol Answer: b) Glucagon Typical onset of gastric emptying delay is: a) Within minutes b) Within hours c) After weeks d) No effect Answer: b) Within hours Semaglutide injection frequency is: a) Daily b) Weekly c) Monthly d) As-needed Answer: b) Weekly A rare but serious adverse effect to monitor is: a) Hypoglycemia b) Pancreatitis c) Hyperthyroidism d) Nephrolithiasis Answer: b) Pancreatitis It is contraindicated in patients with: a) Type 1 diabetes b) Medullary thyroid carcinoma c) Obesity d) Hypertension Answer: b) Medullary thyroid carcinoma Compared to exenatide, semaglutide yields: a) Less weight loss b) More weight loss c) Higher injection frequency d) Less HbAc reduction Answer: b) More weight loss Half-life of semaglutide is approximately: a) 24 hours b) 3 days c) 7 days d) 15 days Answer: c) 7 days Excretion involves: a) High renal elimination b) Only feces c) Metabolism and minimal excretion d) Biliary excretion Answer: c) Metabolism and minimal excretion An added cardiovascular benefit was shown in: a) SUSTAIN trials b) DPP4 studies c) RAAS inhibitor trials d) REM sleep studies Answer: a) SUSTAIN trials Weight loss percentage ranges from: a) 15% b) 510% c) 1017% d) 2025% Answer: c) 1017% A significant GI side effect is: a) Increased appetite b) Nausea c) Insomnia d) Hypertension Answer: b) Nausea Semaglutide metabolism involves: a) CYP3A4 b) Proteolysis c) Renal enzymes only d) Conjugation Answer: b) Proteolysis An advantage over liraglutide is: a) Lower efficacy b) Higher weight loss c) Daily dosing d) Less frequent injection Answer: d) Less frequent injection FAQs Does semaglutide cause weight loss in non-diabetic patients

Clinical studies show comparable effectiveness in blood sugar control and weight loss between daily oral and weekly injectable semaglutide when doses are optimized

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Complete and submit the report online at MedWatch: The FDA Safety Information and Adverse Event Reporting Program, or Download and complete the form, then submit it via fax at 1-800-FDA-0178

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