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As an obesity medicine physician scientist who regularly cares for patients with complex inflammatory conditions, this study reinforces what many of us have suspected clinicallythat the benefits of GLP-1 receptor agonists extend well beyond blood sugar control and weight loss and may fundamentally alter the disease trajectory for some of our highest-risk patients. Although this study cannot prove a causal link between GLP-1 medication and the effects seen on the patients taking them, it opens the door to future combinations of treatments for autoimmune disease with GLP-1 drugs

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The presented review shows not only the importance of ascorbate as a free radical scavenger but also summarizes its antioxidant action based on other mechanisms, including the activation of intracellular antioxidant systems and its effect on the NFB/TNF pathway and apoptosis

Journal of Experimental Pharmacology (2012)