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Apoptosis, another consequence of oxidative damage and mitochondrial dysfunction, was evaluated using Annexin-V staining, which detects early apoptotic changes by binding to phosphatidylserine exposed on the outer leaflet of the plasma membrane

10.1158/0008-5472.CAN-18-1680 Cancer Res

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Metformin pharmacokinetics in mouse tumors: implications for human therapy

For example, magnetic resonance elastography has proven effective in identifying malignant tumors by detecting alterations in stiffness within the breast tissue [74, 240]