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In phase two, SpragueDawley rats (8 weeks old) were randomly assigned to 3 groups and received either purified water, L-citrulline (500 mg/kg/day), or a combination of L-citrulline (500 mg/kg/day) and GSH (50 mg/kg/day) by oral gavage for 3 days

doi: 10.1007/s13238-013-2084-3 39 KamranMZPatilPGudeRP

These findings support the idea that MOTS-C could offset the exercise intolerance and fatigue that sometimes accompanies aggressive caloric restriction from Retatrutide

Tanaka, K