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See DoD 1010.16, Technical Procedures for the Military Personnel Drug Abuse Testing Program

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Pathogenesis of Inflammation Since the brain does not mount classical allergic reactions and IgE cannot cross the blood-brain barrier (BBB), it is therefore unsurprising that mast cells, although distributed systemically, normally lack surface expression of the high-affinity IgE receptor (FcRI)

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The most common side effects are mild and may include temporary pain, redness, or swelling at the injection site