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Even though long-term exposure to NMN may not be favorable for axonal stability or neuron health due to its interaction with Sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1), and by modulating its activity 72,73 , maintaining NAD + / NADH balance appears to be an important contributor to UMN health, especially the ones that are diseased due to TDP-43 pathology

This metabolic-immune crosstalk establishes mucosal tolerance while curbing pathological inflammation (Smith et al., 2013)

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In VEGF inhibition, impaired angiogenesis may contribute to delayed wound healing and skin fragility

Safety concerns arise when smoking cessation medications and anti-TB drugs are co-administered, so predicting and assessing potential DDIs would be extremely helpful