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PDGFR signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity

Side effects may occur.

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Characterization of IOC in the explanted human heart and the animal model Hemojuvelin-deficient mice on an iron-rich diet are an established IOC model that exhibits both systolic and diastolic dysfunction ( 2+ cycling (decrease in SERCa2 levels accompanied by a compensatory increase in NCX levels), metabolic remodeling (inhibition of Akt activity coupled with upregulation of AMPK activity), and oxidative stress (increased MDA levels and low GSH/GSSG ratio)