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Eligibility typically requires a BMI of 30 kg/m or higher, or BMI of 27 kg/m or higher with weight-related comorbidities such as hypertension, dyslipidemia, or obstructive sleep apnea

A mouse model that utilized immunization with CEP to drive a DAMD pathology developed drusen and RPE lesions mimicking those seen in humans with DAMD, a phenotype not naturally observed in mice [181]

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The active ingredient in these injectable medications is semaglutide (Ozempic, Wegovy) or tirzepatide (Mounjaro), which slows digestion in the stomach