And lastly, relying on ineffective patches might delay you from seeking evidence-based medical treatments that could actually help manage your weight and metabolic health
A structured discontinuation plan should include strategies for maintaining glycemic control and weight management, such as initiating alternative medications, intensifying lifestyle modifications, and scheduling appropriate follow-up appointments
GLP-1 Injection Site Reactions: Causes and Fixes GLP-1 medications like Semaglutide (Ozempic, Wegovy) and Tirzepatide (Mounjaro, Zepbound) are effective for weight loss, but about 50% of users experience mild injection site reactions
Caution is warranted when: Weight is stable but distress is high Fatigue, hormonal symptoms, or GI issues are the main concern Under-eating or nutrient deficiency is already present Muscle and bone mass are low, or frailty risk is high There is sarcopenia risk, especially in older adults BMI is in the normal range and use would be off-label without a clear medical rationale In these cases, building nutrition adequacy and strength first may improve symptoms and long-term health more than appetite suppression
Semaglutide and a dual agonist of GLP-1R and glucose-dependent insulinotropic polypeptide receptor, tirzepatide, also positively affect the M1/M2 ratio (Iwamoto et al., 2024)
