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NAC is generally well-tolerated, but it can interact with certain drugs, especially nitroglycerin and some blood pressure medications

doi:10.1016/S0032-9592(98)00055-7 Lorenz E, Schmacht M, Stahl U, Senz M (2015) Enhanced incorporation yield of cysteine for glutathione overproduction by fed-batch fermentation of Saccharomyces cerevisiae

Consistency outweighs exact timing

Steady, continuous delivery Though injections provide better bioavailability than oral medication, bolus administration leads to a peak concentration of the drug in the bloodstream

doi: 10.1016/j.ccc.2012.07.006 Leeming MG, Gamon LF, Wille U, et al