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For adults over 65, no dose adjustment is required, but careful monitoring for adverse effects is prudent as older adults often have multiple comorbidities and medications that increase complication risk

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Fatty acid metabolism and OXPHOS Previous studies have shown that sterols derived from ACs activate transcription factors and nuclear receptors, including PPAR and Liver X receptor alpha (LXR)

A long action profile supports a single weekly subcutaneous injection , and a stepwise dose increase helps keep tolerability high while the body adjusts [3] [4]

Understanding the underlying mechanisms and triggers of hyperpigmentation is essential for selecting appropriate treatment approaches that address the root cause rather than merely masking symptoms