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dose reduction of those agents may be required

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The involvement of these genes suggests a potential link to secretins, as pseudopili act as pistons to push protein cargos through the OM secretin gate 22

The anti-fibrotic effects of SGLT2i have been demonstrated in several CKD animal models [166,167,168,169] and in kidney tissue from patients with diabetic kidney disease receiving empagliflozin, partly due to the down-regulation of pyruvate kinase M2, the rate-limiting enzyme of glycolysis [170]

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