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Preclinical in vivo evidence: energy expenditure, substrate selection, and adiposity In chow-fed mice kept at thermoneutrality, repeated SLU-PP-332 administration increases energy expenditure, lowers RER (favoring fat over carbohydrate oxidation), and reduces adipocyte size, without changing food intake or spontaneous locomotor activity

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Compound 26, a novel HDAC inhibitor incorporating a benzothiazole moiety, effectively inhibits the HDAC6 activity to significantly inhibit the formation and expansion of cysts in an MDCK cyst model, embryonic renal cyst model and Pkd1 knockout mouse model