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The peptide, Semaglutide, is a GLP-1 agonist

At 48 weeks, mean percentage changes in body weight from baseline were approximately: In the 12 mg arm, roughly 100% of participants achieved at least 5% body-weight loss, about 83% reached 15% loss, around 63% achieved 20% loss, and approximately 26% crossed the 25% threshold

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Overexpressed proteins were purified on a Ni-NTA column (Cytiva) with an elution buffer containing 50 mM NaH 2 PO 4 , 300 mM NaCl, and 300 mM imidazole