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Activating the GLP-1 receptors located within the central nervous system and gastrointestinal tract, medications such as GLP-1 and GIP contribute to diminished appetite, augmented feelings of fullness, and enhanced responsiveness to insulin

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Importantly, much of HDLs (and apoA-Is) inhibition of macrophage activation is mediated through altering cholesterol levels in plasma membrane lipid rafts through cholesterol efflux mediated by ABCG1/SR-BI and ABCA1

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