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However, in line with the specificity of CPA, the C-terminal residues of the L585I, L585M, and L585V variants were cleaved in vitro upon exposure to the enzyme for 5 hours at 37 C, as confirmed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis of the C-terminal peptides (Supplementary Table 1)

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They bind to GLP-1 receptors in the brain, pancreas, and gastrointestinal tract, providing sustained stimulation

Circulation 147 (8), e93e621

Moreover, a decline in lipid peroxidation and H 2 O 2 levels was also seen