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Keep a symptom diary during your first month of treatment, noting the timing, severity, and context of any nausea episodes

Dose adjustment strategies: If symptoms are intolerable despite supportive measures, your prescriber may recommend: Slowing the titration schedule (extending time at each dose level) Temporarily reducing to the previous tolerated dose Maintaining the once-weekly injection schedule (timing within the day has limited evidence for efficacy) When to seek medical review: Symptoms persisting beyond 46 weeks at stable dose Inability to maintain adequate nutrition or hydration Weight loss exceeding expected therapeutic effect New or severe abdominal pain Signs of pancreatitis (severe upper abdominal pain radiating to back) Symptoms of gallbladder disease (right upper quadrant pain, jaundice) Patient safety advice : Discuss any dose changes or stopping with your prescriber

A phase-three trial from Eli Lilly on Zepbound as a treatment for cardiovascular complications in diabetes

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Stites T, Storms D, Bauerly K, et al