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Patients must follow Novo Nordisk's titration schedule, which typically advances from 0.25 mg weekly and increases every four weeks until reaching the target maintenance dose

PMID 34015185

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TMAO promotes macrophage infiltration and activation within adipose tissue, driving a shift in macrophage phenotype toward the pro-inflammatory M1 state, contributing to adipose tissue dysfunction, a key hallmark of obesity-related metabolic dysfunction [30, 75]

Physically, the injection itself is usually quite painless, as it is administered just under the skin (subcutaneously) using a very fine needle, typically in the abdomen, thigh, or upper arm