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The decreased levels of LAC in subjects with MDD are linked to shorter leukocyte telomere length (LTL), increased body mass index (BMI), and higher reported rates of childhood trauma and are predictive of lack of antidepressant responses as assessed using the Hamilton depression rating scale-21

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The GshF activities were similar for all three strains when the IPTG concentration was 0.5 mM for ZJ1234 and ZJ12345 and 0.05 mM for ZJ000

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Furthermore, the reduction in bioavailable copper impairs the function of copper-dependent proteins and signaling pathways, including SOD1, copper chaperones (ATOX1, ATP7A), and transcription factors, such as HIF-1 and NF-B [221]

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Side effects are uncommon and typically mild, such as temporary redness or irritation with topical use or slight discomfort at the injection site

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