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Another limitation of the present systematic review is the fact that the protocol was not prepared and it is not registered in the international prospective register of systematic reviews (PROSPERO), which, although not mandatory, is recommended by guidelines on conducting systematic reviews

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Therefore, smokers see messages like poison in every puff with every stick

In this process the important role plays decrease of ex- pression of genes responsible for formation of collagen, elastin and fibronectin, which, in turn, accompanied by metabolic imbalance of fibroblasts, in particular metabolism of fibrillin in these cells [5-10]

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