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Study selection Titles and abstracts of identified studies (694 records for step one and 561 records for step two) were screened by two independent reviewers (ATa and TA)

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Genetic predisposition Besides environmental and epigenetic factors, there may be a genetic predisposition for smoking in people with BD and vice versa that explains, in part, the heightened incidence of TUD and ND in people with BD

The reference group is adults who have never used tobacco