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Surgeon Generals report on smoking soon after it was released

Metabolism of polynuclear aromatic hydrocarbon in human term placenta influenced by cigarette smoke exposure

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Discussion In this study, we found that cigarette exposure, both former and current smoking, was positively associated with the prevalence of trouble sleeping and depression, and the associations of current cigarette consumption with trouble sleeping and depression were stronger in females than that in males

Medicinal Use Medicinally, nicotine has been used for appetite suppression, increasing metabolism, and as an alternative to smoking (such as with nicotine gums, lozenges or patches)