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These numbers rose to almost 20.000 e-liquids in the 2021 Dutch market [13] while a 2020 survey conducted in France revealed that nearly 27.000 e-liquids were available on the market [14]

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A better understanding of the physiopathogenic mechanisms involved in CR could lead to better treatment for these patients.3,4 OBJECTIVES In the present paper we reviewed the evidence pointing towards the cigarette smoke effects on the respiratory epithelium as well as its role on the pathophysiology of chronic rhinosinusitis

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