Following menthol administration, male rats self-administered more intravenous nicotine infusions and increased their motivation to obtain nicotine (151), and male mice self-administered electronic cigarette vapor containing menthol and nicotine at greater levels than nicotine vapor alone (61)
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Past history and symptoms Allergy/atopy was present in at least one first degree relative (mother, father, sibling or half-sibling) in 72 children (24 %, unknown 13), rhinitis in 82 (27 %, unknown 11) and asthma in 64 (21 %, unknown 12)