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While treating your sting at home, you should: wash the sting area with soap and water to remove as much of the venom as possible apply a cold pack to the wound site to reduce swelling and pain keep the wound clean and dry to prevent infection cover with a bandage if desired The following home remedies can also help: hydrocortisone cream or calamine lotion, if itching or skin irritation becomes bothersome baking soda and colloidal oatmeal used during a bath or in the form of medicated skin creams, to help soothe the skin OTC pain relievers, such as ibuprofen, to help manage pain associated with wasp stings