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Studies reporting a significant association: summary and critical appraisal Despite the studies above being reassuring in lacking statistically significant evidence of respiratory outcomes of EC use by both youth and adults who never smoked, other studies have reported mixed outcomes indicating possible respiratory risks following EC use

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Louisville's tobacco warehouses, auction houses, and manufacturing facilities were economic anchors for the region across much of the twentieth century, and Brown and Williamson's presence there, particularly after the 1929 relocation of its main operations, made the company one of the city's defining employers and institutions

Well, with vaping, you only have to take as many puffs as you need to manage your nicotine cravings, although it may be hard with all the tasty flavours available

Ethics declarations Ethics approval and consent to participate Not applicable Consent for publication Not applicable Competing interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper