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URL: www.imperialbrandsplc.com/content/dam/imperial-brands/corporate/investors/presentations/investor-day/2013/Investor%20Day_4_JPS_Feb%202013_Script.pdf.downloadasset.pdf (accessed 30 September 2019)

Mitochondrial damage associated with apoptosis and necrosis can release damage-associated molecular pattern molecules (DAMPs) and histones that activate inflammatory pathways to exacerbate the lung disease ( FIGURE 1 2.1 Mechanisms of mitochondrial dysfunction Mitochondrial dysfunction can arise through a wide array of genetic and environmental factors and has been implicated in a wide variety of pathological states

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