We do know that it can irritate your gums in the short term, and some people find that nicotine gives them an upset stomach. Morean also notes that nicotine is a stimulant
Food and Drug Administrations website has a notice, saying it is now illegal for retailers to sell tobacco to people under 21
[385] Polozhenie o vyborakh Verkhovnyi Sovet SSSR, Pravda, 2 July 1937, 1
Effects of Nicotine as a Depressant Relaxation: After the initial stimulant phase, nicotine can induce feelings of relaxation and reduce stress and anxiety
For I remember very well, in a discourse one day with the King, when I happened to say there were several thousand books among us written upon the art of government, it gave him (directly contrary to my intention) a very mean opinion of our understandings