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This guidance is consistent with current clinical knowledge about disorders associated with the use of e-cigarette, or vaping, products

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Unfortunately, the tools available to probe this target are limited (Viana & Ferrer-Montiel, 2009), and it is therefore difficult to predict whether single TRPA1 or TRPV1 therapies or a combined drug would be more effective in treating heightened sensory nerve responsive disease states (Belvisi et al., 2011)

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