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Further studies have found that MIF, as a determinant factor of ROS production after vascular endothelial cells were exposed to CS, affected the apoptosis signal-regulating kinase 1 (ASK1) P38 kinase cascade, regulated the activity of XOR enzymes produced by ROS and antagonized ASK1-p38-dependent pulmonary vascular endothelial cell apoptosis

A recent analysis in the journal Tobacco Control , based on data from five national surveys, found that downward trends in smoking by teenagers and young adults accelerated as e-cigarette use in those groups took off

doi: 10.7888/juoeh.39.201

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2016: FDA starts regulating e-cigarettes