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Asbestos was first used in the manufacture of yarn, and German industrialist Louis Wertheim adopted this process in his factories in Germany

Gerstein HC, Sattar N, Rosenstock J, Ramasundarahettige C, Pratley R, Lopes RD, et al

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Furthermore, the authors proposed a mechanism-of-action, whereby 2 -agonists stimulate adenylyl cyclase, leading to cyclic AMP accumulation, activation of protein kinase G, and opening of large conductance calcium-activated potassium (BK Ca ) channels, thereby inhibiting sensory nerve depolarisation