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Even ingredients labeled as generally recognized as safe (GRAS) for ingestion may be harmful when inhaled

Swallowing nicotine-infused spit continually can cause a few minor but annoying side effects: Upset stomach Heartburn Irritated throat Hiccups Unpleasant aftertaste The severity and frequency of these issues will also depend on the nicotine content in your pouches and your tolerance to the chemical

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[89] Comorbid clinical depression, personality disorders and alcohol abuse are known risk factors for treatment failure