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The animal protocol for this work was approved by the Animal Care and Use Committee of ZUJ, and all work was conducted in accordance with the Helsinki guidelines for animal research ( n = 8), Nicotine Group ( NIC ) ( n = 8), Nicotine and ASA 15 mg/kg Group ( NIC/ASA15 ) ( n = 8), Nicotine and ASA 30 mg/kg Group ( NIC/ASA30 ) ( n = 8), and ASA 30 mg/kg Group ( ASA30 ) ( n = 8)

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