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Mechanisms Nicotine is a well-established respiratory irritant 58 , but other chemicals in e-cigarettes (e.g., diacetyl 59 , propylene glycol, carbon monoxide, and formaldehyde 60 ) also have detrimental effects for lung function including respiratory volume 61

France banned nicotine pouches in 2026, while countries such as Belgium and the Netherlands have also enacted prohibitions

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With that as the setup, the film already embraced many ideas that family-friendly comic book-based movies would shy away from, making Constantine 's R-rating seem appropriate, even if it wasn't the studio's original intention

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