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Competition is similarly lacking for tobacco, where a small number of transnational companies dominate most markets, providing clear economic justification for pricing regulation." Concerns have recently been raised about the methods used by tobacco companies to counter tax rises

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To minimise the potential impact of changes in smoking behaviour and higher mortality in those with baseline illness (also known as reverse causality or the sick quitter effect), participants with a self-reported history of doctor-diagnosed cancer other than melanoma and/or non-melanoma skin cancer (n = 30,393, 11%) and those with a history of cardiovascular disease at baseline, defined as self-reported doctor-diagnosed heart disease, stroke, or blood clot on the baseline questionnaire (n = 30,548, 11%) were excluded from this study

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In general clozapine induced agranulocytosis is not thought to be dose dependent but increased drug concentrations specifically in leukocytes could be a factor and may be influenced by genetic variants