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In November of 2019, one doctor said that vaping was highly addictive for specifically young people

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Thus, these individuals presumably would not have had any change in potential CO protection or ANA prevalence between Periods 1 and 2, since vaping did not begin until 2007, but would have had a decrease in potential CO protection and, consistent with our hypothesis, a corresponding increase in ANA prevalence between Periods 2 and 3, as some of them took up vaping

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China remains the largest player by volume but is largely confined to the domestic Chinese market despite incremental global forays