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Withdrawal symptoms may include being irritable, anxious or restless

At the end of 16th century it becomes popular in Western Europe, tobacco begins to be cultivated in Turkey, at that time merchants brought it to Russia

"There's the very big concern of the so-called gateway effect, that it leads people on to feel familiar with smoking and then to think of taking up tobacco cigarettes, so there are multiple levels of harm," Professor Kelso said

Smoking protocol The number (n) of investigated cigarettes of each brand varied between 15 and 41 (Table 1)

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