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The government also set out a path for uprating tobacco duties by Retail Prices Index (RPI) +2%

[43] Health concerns [edit] Nazi Germany saw the first modern anti-smoking campaign, [44] the National Socialist government condemning tobacco use, [45] funding research against it while levying increasing sin taxes on tobacco products, [46] and in 1941 banning tobacco in various public places as a health hazard

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In human liver microsomes, CYP3A4 rather than CYP2B1 mediates pyridine oxidation of NNK [88] (Fig