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Elevation of ROS levels results in oxidative stress in airway epithelial cells which activates an antioxidant defence mechanism known as the Keap1Nrf2 pathway to counteract the harmful effects of oxidative stress (Schieber and Chandel 2014)
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Joinpoint computes the average annual percentage change (AAPC) and 95% confidence intervals (CIs) for each outcome, testing to determine if the average trend is significantly different than zero at the alpha = 0.05 level 35
Online tobacco transactions are heavily restricted and must comply with licensing and age verification rules
The application uses live pollution data from air quality stations across the globe and translates it into a cigarette equivalency
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