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Finally, the alternative pathway is continuously active at low levels due to the spontaneous hydrolysis of C3, a condition known as C3 tick over ( Figure 1 At the heart of the action of the complement system is the cleavage of the C3 protein into C3b and C3a by the C3 convertases formed by the trigger of the canonical pathways (classical, alternative, and lectin)

1998 Modern Epidemiology

These substances are detectable in oral fluid attributable to their swift absorption into the bloodstream and subsequent secretion into saliva