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The analyses primary outcomes of interest were the six-month continuous abstinence rate, defined as self-reported abstinence with no more than five cigarettes over six months and none in the preceding seven days, a commonly used clinical outcome in cessation trials

[74] Dosage The first factor, dosage, has been a truism since ancient times, or at least since Paracelsus who said, "Dose makes the poison." Some compounds are beneficial or pleasurable when consumed in small amounts, but harmful, deadly, or evoke discomfort in higher doses