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Your dog will be in danger of death if they have consumed between 9 and 12 milligrams of nicotine per kilogram of body weight (or approximately 5 milligrams per 1 pound of body weight), but clinical signs can be seen at much lower doses, even at 1 milligram per kilogram

This guide covers four key design factors - thickness, materials, surface texture, and manufacturing - plus practical testing methods and troubleshooting solutions

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Hammond, D., Wiebel, F., Kozlowski, L.T., Borland, R., Cummings, K.M., O'Connor, R.J., McNeill, A., Connolly, G.N., Arnott, D., Fong, G.T., 2007