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However, despite its protective role, the constant activation of the Nfr2 pathway in response to e-cigarette use, particularly the flavouring agents found in e-cigarettes, can exhaust this protective pathway, leading to eventual cellular death in the epithelium (Ma et al

incidence rate difference, 0.38 [95% CI, -0.57 to 1.56]) (eTable 7 in the Supplement)

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The native microorganisms isolated from tobacco could avoid the adverse effects caused by adding exogenous microorganisms, thus playing an important role in increasing aroma content and improving tobacco quality (Liu et al