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Its a bit like baking a caketoo much or too little of an ingredient can completely change the outcome

The G allele of a second variant in the region, rs7096169 (intronic to BORCS7 and only in weak LD with rs12780116, r 2 = 0.18 in 1000G Europeans) increases smoking initiation and reduces expression of BORCS7 and AS3MT in eight brain tissues (including dorsolateral prefrontal cortex in the Brain xQTL and was the top BORCS7 eSNP in GTEx in the Cerebellar Hemisphere, Cerebellum, and Spinal cord cervical-C1)

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Key Features: Delicious Fusion: Enjoy the harmonious combination of rich chocolate and strong tobacco notes in every puff

Nature Rev