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Recognizing these limitations there has been a shift by the toxicological community towards more holistic alternative systems biology approaches

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In recent years, the Warburg effect has been linked to inflammatory phenotypes in autoimmune diseases and chronic infectious diseases (including asthma and COPD) as well as cancer, showing that aberrant immune responses and the property of immune cells to divide and proliferate can utilize the same metabolic pathways to provide fuel for increased effector responses (Figure 1)