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Under hypoxic conditions, LC3 overexpression promotes necroptosis, whereas under normoxic conditions, impaired autophagic flux results in elevated RIPK1 and RIPK3 levels, subsequently triggering necroptosis (89)

Surprisingly, we observed no significant transcriptional differences in other mitochondrial fission (Fis1 and Drp1) or fusion markers (Mfn1 and Mfn2) nor in Tfam expression (Figure 2)

Reports of severe intoxication and dangerous health effects associated with the use of bath salts have made these drugs a serious and growing public health and safety issue

According to a 2022 report by the Substance Abuse and Mental Health Services Administration (SAMHSA), prevention programs in schools have led to a 30% reduction in stimulant misuse among young adults